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Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: jkm89 on June 11, 2009, 09:21:56 PM

Title: Difference between oxycodone and hydrocodone
Post by: jkm89 on June 11, 2009, 09:21:56 PM
What is the difference between oxycodone and hydrocodone? I know there is an extra OH group that comes off of oxycodone, but why does this make it a stronger opiate?
Title: Re: Difference between oxycodone and hydrocodone
Post by: AWK on June 12, 2009, 02:53:52 AM
Check both terms on wikipedia
Title: Re: Difference between oxycodone and hydrocodone
Post by: limpet chicken on June 14, 2009, 11:33:58 AM
AFAIK its largely because the -OH group is a large, polar zit on hydrocodone's face, and won't pass the BBB so easily as will oxy, as well due to being less lipophillic than the ox.
Title: Re: Difference between oxycodone and hydrocodone
Post by: jkm89 on June 14, 2009, 02:36:01 PM
No, the OH group is on oxycodone.