Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: xaxax on June 29, 2011, 06:57:47 PM
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I want to carry out the reaction of primary alcohol from carboxylic acids. I will add carboxylic acid and LiAlH4 into the flask in dry diethyl ether, and i will do this reaction at 30C for 2 hours.
while there is produced alcohol, there is also produced water, and water reacts with LiAlH4 quickly.
how should i do this reaction?
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I want to carry out the reaction of primary alcohol from carboxylic acids. I will add carboxylic acid and LiAlH4 into the flask in dry diethyl ether, and i will do this reaction at 30C for 2 hours.
while there is produced alcohol, there is also produced water, and water reacts with LiAlH4 quickly.
how should i do this reaction?
Use BH3.DMS
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BH3 works or use an excess of LAH
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BH3 works or use an excess of LAH
Work up is easier with BH3
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If you start with an acid, a borate ester intermediate will react better than the lithium salt of your acid. I too prefer doing a diborane reduction.