Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: Kaladiscope on June 19, 2012, 07:48:27 PM
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Sorry guys,
I would like to ask u how does it call the following reaction:
R1MgBr + R2-OMs ------> R-2-R1 + MsOMgBr
Is it a Grignard reaction?
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Sorry guys,
I would like to ask u how does it call the following reaction:
R1MgBr + R2-OMs ------> R-2-R1 + MsOMgBr
Is it a Grignard reaction?
Yes it is a Grignard reaction. It is also a variant of the Wurtz coupling this uses sodium.
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Thanks!
Do u think that Cadmiun could be better than magnesium in such reaction?
Like forming first the cadmiun derivative:
R-CH2Br + Cd ----> R-CH2CdBr
and then reacted it with for example:
R-OMs + RCH2CdBr -----> R-CH2-R + MsOCdBr
It is mesylate a good leaving group for this case?
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Thanks!
Do u think that Cadmiun could be better than magnesium in such reaction?
Like forming first the cadmiun derivative:
R-CH2Br + Cd ----> R-CH2CdBr
and then reacted it with for example:
R-OMs + RCH2CdBr -----> R-CH2-R + MsOCdBr
It is mesylate a good leaving group for this case?
Organocadniums are known, see e.g. http://en.wikipedia.org/w/index.php?title=Organocadmium_compound&oldid=493342441. Whether they are better, is diffiicult to say - I would imagine the toxicity may be a key point, both for the metal and the anion equivalent.