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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: minimumlong3 on September 06, 2018, 04:53:11 PM

Title: Help troubleshooting a Buchwald-Hartwig amination?
Post by: minimumlong3 on September 06, 2018, 04:53:11 PM

Does anyone have any experience in Pd cross-coupling reactions that could help me? I'm trying to couple an aryl chloride (that has a alcohol protected by a TBDMS and an heterocycle) with a alkylamine with a phenol at the end of it. I'm getting weird products (multiple TBDMS signals when there should only be one). Also, my "product" tends to have a higher Rf than both of my reagents, if someone knows anything about this I would be very grateful!
Title: Re: Help troubleshooting a Buchwald-Hartwig amination?
Post by: Borek on September 06, 2018, 05:35:05 PM
Please don't cross post.

Locked here.