You can draw an MO diagram with hybridized atomic orbitals. This combines VSEPR and MO models to try and get a general understanding of bonding character in molecules that have more than 2 bonds.
MO alone is good for simple diatomic molecules.
For example, MO works well for O2 and NO2, but not for many organic compounds and this such example. Otherwise you'll wind up combining a lot of p orbitals and it can get rather messy.