[Fry]

Hey I looked around through some papers to see what sort of conditions the amide group would hydrolyze at and I found this paper " Studies of the Thermal Degradation of Acetaminophen Using a Conventional HPLC Approach and Electrospray Ionization-Mass Spectrometry"..

It would have been really helpful except its not available online and I dont have access to the resources for the hardcopy at the moment. Can anyone tell me what sort of reacting conditions would be needed to efficiently cleave this amide group (acid catalyzed) ? I figure its fairly stable compared to most amides due to the electron donating effect of the hydroxy group but I would like some specific pHs and temperatures if its possible..

Thanks