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Topic: detection limit  (Read 3603 times)

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Offline luvmona20

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detection limit
« on: March 31, 2009, 08:32:05 AM »
hi,this question is related to detection limit.how can i calculate detection limit (at signal to noise ratio=3)from a calibration plot?
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Offline JGK

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Re: detection limit
« Reply #1 on: April 06, 2009, 10:01:04 AM »
Using the standard deviation (SD, from replicate injections of your lowest STD), the LOD is calculated as follows:

LOD = 3.3 x SD / Slope,  also LOQ = 10 x SD / slope

As listed in the ICH Q2 (R1) guidelines
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