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Topic: 4-iodotoluene synthesis  (Read 5435 times)

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Offline lasset

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4-iodotoluene synthesis
« on: April 27, 2009, 04:15:14 PM »
So basically it's a Sandmeyer reaction, but I've got a scheme which dosen't use a copper catalysit.

The simplified procedure looks like this: p-toluedine is dissolved in HCl then a NaNO3 solution is added. Then I add carbamide, then KI solution(everything is done in a low temperature) Then I heat the mixture and add NaOH.

So I would like to know what is the function of carbamide and NaOH.


Offline aldoxime_amine

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Re: 4-iodotoluene synthesis
« Reply #1 on: April 28, 2009, 10:56:39 AM »
Is it theoretical or did you actually synthesize the required compound like this?

Offline Squirmy

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Re: 4-iodotoluene synthesis
« Reply #2 on: April 28, 2009, 11:05:53 PM »
Just searching around, it looks like urea (carbamide) is there to get rid of any leftover nitrous acid.

Offline lasset

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Re: 4-iodotoluene synthesis
« Reply #3 on: May 03, 2009, 03:10:48 PM »
I really synthesized it like this

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