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Author Topic: Difference between oxycodone and hydrocodone  (Read 5044 times)

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jkm89

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Difference between oxycodone and hydrocodone
« on: June 11, 2009, 03:21:56 PM »
What is the difference between oxycodone and hydrocodone? I know there is an extra OH group that comes off of oxycodone, but why does this make it a stronger opiate?
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AWK

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Re: Difference between oxycodone and hydrocodone
« Reply #1 on: June 11, 2009, 08:53:52 PM »
Check both terms on wikipedia
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limpet chicken

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Re: Difference between oxycodone and hydrocodone
« Reply #2 on: June 14, 2009, 05:33:58 AM »
AFAIK its largely because the -OH group is a large, polar zit on hydrocodone's face, and won't pass the BBB so easily as will oxy, as well due to being less lipophillic than the ox.
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jkm89

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Re: Difference between oxycodone and hydrocodone
« Reply #3 on: June 14, 2009, 08:36:01 AM »
No, the OH group is on oxycodone.
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