I have kind of gone in the other direction, working on enantioselective transition metal chemistry and total synthesis in grad school to what amounts to medicinal chemistry (with some enantioselective catalysis) for my postdoc. It is always good to learn new things!
Ah, medchem with chirality excites me. Belated congrats, and good luck. Yeah, I wanted to try something new - I spent 4.5 years doing target synthesis from the carbohydrate chiral pool with no need for asymmetric catalysis, loved it, but I thought catalysis methodology would be an interesting way to broaden my experience.
The weird thing is going back into the lab as a properly paid professional having been out of the lab for months with writing up, conference, moving cities. Your hands don't quite know what to do at first! Ah, but the feel of purple nitrile on your skin again... a pair of tweezers in your hand, a new manifold in your hood and a faint whiff of EtOAc in your nostrils. It feels good. I actually missed
doing columns - I never thought I would!