I am new to this forum. Just to say hi to all of you first.
I got trouble with Raney Ni reduction of nitrile into primary amine. I either have no reaction or reduction to give a mixture of products. since it is my first time to deal with Raney Ni, I wonder I have not captured some tricks in doing such reduction.
The procedure I use is: weigh a slurry of activated Raney Ni in water, wash with methanol for three times, add in my substrate, stir vigorouly, equip with a H2 balloon, fill the flask with H2 gas, and that's it.
Can anyone give some suggestions to me? thank you!