First off, I'd like to introduce myself, as this is my first post here. I am a senior at a state university getting my degree in chemistry.
I have to do a presentation on a name reaction that was selected for me by my professor at the end of the semester, and I was given the Wolff-Kishner reduction with the Huang-Minglon modification.
I feel like there isn't as much information about this reaction as there is about the other reactions that were given to other students (for example, the Birch reduction).
I have to give a history of the reaction, the scope and limitations of the reaction, and how it is used in organic synthesis today.
I had a few questions that I would really appreciate if someone gave me some help with.
First, will the Wolff-Kishner reduction react with any other functional groups to produce undesirable side products?
Will it break certain ring structures? For example, would it crack open a methylenedioxy ring?
Are there certain ketones (or aldehydes) that will not participate in the reaction? For example, when preparing oxindole from isatin, why aren't both ketones reduced? Does it have to be a beta ketone?
Lastly, why and when would the Huang-Minglon modification be preferred over the two-step Wolff-Kishner reduction? Does the one=pot reaction lead to higher yields?
Thanks for the help, I really appreciate it.