Hi chemists, biochemist or whatever involved in science...
Let's guess that we have an alkyl chain like CH3-CH2-CH2-N3, that we can to use it as a substrate to perform on the azide a nucleophilic attack. And at the same time we perform the same reaction on an alkyl chain which have difluoromethyl instead of methylene, that is CH3-CF2-CH2-N3.
My question or better to say my assumption is:
Due to the presence of a difluoromethyl in the second case, and therefore making the azide more electrophilic (electronwithdrawing effect of the fluor atom), the nucleophilic attack on this azide would be faster than in the first case having an alkyl chain.
Is that right?