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Topic: Cycloaddition in the presence of an activated center  (Read 2149 times)

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Offline Nescafe

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Cycloaddition in the presence of an activated center
« on: October 23, 2012, 06:41:36 PM »
Hi,

I was wondering if there is anything to worry about if I were to react BrCH2-C≡CH with R-N3 via the traditional click chemistry methods. What are the odds of the azide reacting with the bromine? I imagine this is not very likely?

Nescafe.

Offline Doc Oc

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Re: Cycloaddition in the presence of an activated center
« Reply #1 on: October 24, 2012, 02:59:46 PM »
Alkyl azides are less nucleophilic than the salt forms (for obvious reasons).  That's not to say nothing will go wrong, but I don't anticipate it coming from that end.

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