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Author Topic: NMR Reference  (Read 171 times)

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HailoMan

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NMR Reference
« on: September 25, 2016, 06:49:52 PM »

Apology in advanced if this is a silly question, but in calibrating 1H NMR spectra, can I use water residue as a reference instead of the internal solvent residue?
I did a 1H NMR measurement of gamma-valerolactone (GVL) in DMSO-d6. The DMSO residue peak (2.50 ppm) happen to overlap with 2 of the proton peaks of GVL, so I can't use the DMSO as an internal standard.
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discodermolide

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Re: NMR Reference
« Reply #1 on: September 26, 2016, 12:03:33 AM »

Surely this compound should be soluble in chloroform? Then you can use that as the reference.
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Babcock_Hall

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Re: NMR Reference
« Reply #2 on: September 26, 2016, 04:13:03 AM »

The chemical shift of water depends upon temperature; therefore, one would have to take this into account.
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HailoMan

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Re: NMR Reference
« Reply #3 on: Yesterday at 09:58:27 PM »

Surely this compound should be soluble in chloroform? Then you can use that as the reference.

Unfortunately, the compound (nitrogen-doped carbon nanotubes) is non-dispersible in chloroform or other common NMR solvents.

The chemical shift of water depends upon temperature; therefore, one would have to take this into account.

Thank you for this information. I will look into it.
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