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Topic: Cyclic ether formation  (Read 1731 times)

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Offline p-orbs

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Cyclic ether formation
« on: September 20, 2014, 01:03:34 PM »
I'm looking over some exam problems and came across this one (image).
The task is to suggest mechanism and reagents.

Is the ketone reduced to an alcohol before a Williamson ether synthesis or is the solution much simpler?
Appreciate some help/suggestions!

Offline discodermolide

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Re: Cyclic ether formation
« Reply #1 on: September 20, 2014, 01:05:49 PM »
It is actually easy. No reduction involved. No Williamson.
Google  ketone protecting groups.
Development Chemists do it on Scale, Research Chemists just do it!
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Offline p-orbs

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Re: Cyclic ether formation
« Reply #2 on: September 20, 2014, 01:38:54 PM »
Got it! Thank you!  :)

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