[Paulie]

Hi,

As part of my master's thesis I have to find out how the β-blocker metoprolol, marketed as Lopressor by Novartis and Betaloc by AstraZeneca, is made commercially. I have searched for patents and looked through everything on Novartis' and AstraZeneca's websites, but can't find anything. Does anyone have any idea where I can find this sort of information?

[kriggy]

I found this
http://en.wikipedia.org/wiki/Metoprolol#Chemistry
There might be some moden methods but it might be good place to start.