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Topic: Benzaldehyde acetal protecting group  (Read 2070 times)

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Offline AlphaScent

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Benzaldehyde acetal protecting group
« on: April 14, 2015, 05:33:58 PM »
Can you get away with protecting a 1,2-diol with benzaldehyde acetal in the presence of an epoxide??
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Offline discodermolide

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Re: Benzaldehyde acetal protecting group
« Reply #1 on: April 14, 2015, 09:00:24 PM »
It would be more prudent to protect the diol first then make the epoxide.
If you used tosic acid and anhydrous copper sulphate it may just work.
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