April 26, 2024, 09:03:09 AM
Forum Rules: Read This Before Posting


« previous next »
Pages: [1]   Go Down

Topic: Retrosynthesis of STEPHANINE  (Read 3284 times)

0 Members and 1 Guest are viewing this topic.

Offline marmar

  • New Member
  • **
  • Posts: 6
  • Mole Snacks: +0/-0
Retrosynthesis of STEPHANINE
« on: May 27, 2015, 05:57:37 AM »
Hi everyone,

I would really kindly ask you if anyone know the path of retrosynthesis and synthesis of STEPHANINE (including all reagents).

Thank you very much!
Logged

Offline Borek

  • Mr. pH
  • Administrator
  • Deity Member
  • *
  • Posts: 27664
  • Mole Snacks: +1801/-410
  • Gender: Male
  • I am known to be occasionally wrong.
    • Chembuddy
Re: Retrosynthesis of STEPHANINE
« Reply #1 on: May 27, 2015, 06:12:33 AM »
Please read the forum rules.

You have to show your attempts at solving the question to receive help. This is a forum policy.
Logged
ChemBuddy chemical calculators - stoichiometry, pH, concentration, buffer preparation, titrations.info

Offline marmar

  • New Member
  • **
  • Posts: 6
  • Mole Snacks: +0/-0
Re: Retrosynthesis of STEPHANINE
« Reply #2 on: May 27, 2015, 09:49:09 AM »
Thank you for your warning and apologise I did not take into account Forum rules.

I attach some of my attempts but I am missing the reagents and some additional steps. First picture is retrosynthesis and the second is synthesis of stephanine...
Logged

Offline marmar

  • New Member
  • **
  • Posts: 6
  • Mole Snacks: +0/-0
Re: Retrosynthesis of STEPHANINE
« Reply #3 on: May 28, 2015, 08:15:36 AM »
No idea??  ??? ???
Logged

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Retrosynthesis of STEPHANINE
« Reply #4 on: May 28, 2015, 08:20:21 AM »
Lots of ideas, what about sowing us some of yours to get started?
Try reagents.
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History

Offline marmar

  • New Member
  • **
  • Posts: 6
  • Mole Snacks: +0/-0
Re: Retrosynthesis of STEPHANINE
« Reply #5 on: May 28, 2015, 08:39:30 AM »
I made some additions, can you please check it...
Logged

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Retrosynthesis of STEPHANINE
« Reply #6 on: May 28, 2015, 12:24:10 PM »
So which book did these pictures come from?
If you are asking for reagents, they are already in the picture you posted last. Do you have any alternatives to those? Is there anything in the book?
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History

Offline marmar

  • New Member
  • **
  • Posts: 6
  • Mole Snacks: +0/-0
Re: Retrosynthesis of STEPHANINE
« Reply #7 on: May 28, 2015, 12:26:42 PM »
There is almost no literature about this.
This pictures are from my PowerPoint presentation that I present tomorrow. That's the reason I need any confirmation my mechanism is correct.
Logged

Offline sjb

  • Global Moderator
  • Sr. Member
  • ***
  • Posts: 3652
  • Mole Snacks: +222/-42
  • Gender: Male
Re: Retrosynthesis of STEPHANINE
« Reply #8 on: May 28, 2015, 12:51:08 PM »
Compare and contrast e.g. http://dx.doi.org/10.1039/JR9580001876 or similar. What advantages do both have?

One of the things about retrosynthesis is that right and wrong is rarely black and white.
Logged

Offline marmar

  • New Member
  • **
  • Posts: 6
  • Mole Snacks: +0/-0
Re: Retrosynthesis of STEPHANINE
« Reply #9 on: May 28, 2015, 01:37:29 PM »
Unfortunately I have no access to this article.
Logged

Offline discodermolide

  • Chemist
  • Sr. Member
  • *
  • Posts: 5038
  • Mole Snacks: +405/-70
  • Gender: Male
    • My research history
Re: Retrosynthesis of STEPHANINE
« Reply #10 on: May 28, 2015, 02:09:38 PM »
Check out some standard literature on alkaloid synthesis. Try a google search.
Pictet-Spengler reaction etc.
Logged
Development Chemists do it on Scale, Research Chemists just do it!
My Research History
Pages: [1]   Go Up
« previous next »
Sponsored Links