[Exploring]

Hi all!
I would like to know could I get rid of the excess of terephtalic acid in my final reaction product. It does not dissolve in anything (but some ionic liquids) , and I am not sure esther derivatisation (and then dissolve it) is a trouble free option.
I normally use it as a limiting reactant but sometimes it does not get consumed in a 100%.
Any practical suggestion??
Thanks

[clarkstill]

I presume washing it away with base is out of the question for some reason?

[TTF]

Hi all!
I would like to know could I get rid of the excess of terephtalic acid in my final reaction product. It does not dissolve in anything (but some ionic liquids) , and I am not sure esther derivatisation (and then dissolve it) is a trouble free option.
I normally use it as a limiting reactant but sometimes it does not get consumed in a 100%.
Any practical suggestion??
Thanks

Seperate with column chromotography is your best option, just a simple silica column, and terephthalic acid does dissolve in DMSO if I recall correctly, you could try that, but it will most likely dissolve your product too

[Dan]

I would like to know could I get rid of the excess of terephtalic acid in my final reaction product. It does not dissolve in anything

What about the solubility of your product? Can you just remove the terephthalic acid by filtration?

[CKabes]

There are lots of things you could do, but it depends on the sensitivity of the product you want to keep. What else is in your mixture?

[Exploring]

thanks to all for the answers. Basically I am preparing a MOF which is insoluble, and sensible to bases… I will try DMSO, however, it will be very difficult to get rid of it after washing

[TTF]

thanks to all for the answers. Basically I am preparing a MOF which is insoluble, and sensible to bases… I will try DMSO, however, it will be very difficult to get rid of it after washing

If your MOF isn't water sensitive you can wash the DMSO out with water and then heat to 100-120 under vacuo for 24-48 hours, to dry it. Generally frameworks have to be dried that long anyways (At least in my case they are).

e/ Also another thing you can try is hot methanol, I use a similar precursor (1,3,5 tricarboxylic acid instead of para) and that dissolves it very well.