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Topic: O-methylation of keto-enol compound  (Read 2462 times)

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Offline pallidol

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O-methylation of keto-enol compound
« on: August 02, 2015, 11:18:31 AM »
Hi guys

I need some help regarding my work. My starting material is in keto-enol form (as per attached). NMR showed it was in keto form when it is dissolved in CDCl3 and enol form in DMSO.

I need to proceed the O-methylation. Unfortunately the C-methylation was formed.

Any suggestion guys?
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Offline Dan

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Re: O-methylation of keto-enol compound
« Reply #1 on: August 03, 2015, 08:11:49 AM »
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Offline discodermolide

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Re: O-methylation of keto-enol compound
« Reply #2 on: August 03, 2015, 10:02:29 AM »
Try a different methylating agent, dimethylsulfate or diazomethane for example
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Offline pallidol

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Re: O-methylation of keto-enol compound
« Reply #3 on: August 03, 2015, 11:43:18 PM »
ok tq guys for the help  ;)
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