March 29, 2024, 10:11:16 AM
Forum Rules: Read This Before Posting


Topic: Help with Average Charge Question On Ionizable Functional Group of a Protein  (Read 1909 times)

0 Members and 1 Guest are viewing this topic.

Offline student12393

  • Very New Member
  • *
  • Posts: 1
  • Mole Snacks: +0/-0
So the question is as follows:

A hypothetical protein with a single ionizable functional group takes on a charge of -1 when deprotonated. Find the equation for the average charge Z on the molecules as a function of pH and pKA of this functional ionizable group.

So the only equation I know of in regards to charge "Z" is the the Ionic Strength formula which is I = 1/2 Ī£(i) ciZi^2. I'm not sure how to relate this at all with pH or pKA, and have had no luck when trying to come with something using the Hendersonā€“Hasselbalch equation.

Sponsored Links