March 29, 2024, 02:50:03 AM
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Topic: How to interpret number-weighted and unweighted DLS data for liposomes?  (Read 1515 times)

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Offline heyhey

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Hello,

Three Questions:

(1) I understand how number-weighted is determined and some basic info about it, but what exactly does unweighted even mean?

(2) How do I interpret number-weighted and unweighted data side by side? For instance, if my number weighted data says that my liposomes are 7 nm (1.0 contribution) and my unweighted data says that they are 9 nm (1.0 contribution) then what exactly should I assume I have in my sample? A mix of both particle sizes or a majority of 8 nm (in the middle) or???

(3) What is considered as a significant contribution besides 1? If another size has 0.9 contribution is this size considered to have a significant population as well?

Really appreciate the help.

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