[maverick1996]

Heyy!!

So I am reacting an aldehyde/ketone with a primary amine and for this example lets say I have Et-COH and reacting it with PhNH2 (forming PhN=CHEt), how would I know which product is formed? Cis or trans imine?

Has it got to do with the steric repulsion and that the trans isomer is therefore preferred?

Thank youuu

[Dan]

Has it got to do with the steric repulsion and that the trans isomer is therefore preferred?

Generally yes. Imine formation under most standard conditions is reversible, leading to the more thermodynamically stable product.

[maverick1996]

Thank you