March 28, 2024, 01:08:39 PM
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Topic: side reaction in the amide coupling of acid containing cyano group  (Read 1418 times)

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Offline anupree86

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Hi everyone,

i tried amide coupling of  acid containing cyano group with EDCI and HObt conditions. Is there any possibility of side reaction through cyano group.

Thanks.

Offline Doc Oc

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Re: side reaction in the amide coupling of acid containing cyano group
« Reply #1 on: April 25, 2016, 04:11:40 PM »
No, the cyano group will not interfere with a peptide coupling

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