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Topic: About borate esters...  (Read 1447 times)

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Offline Richard Jeong

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About borate esters...
« on: September 17, 2016, 12:50:54 AM »
Is borate ester a good leaving group as halogen?

if yes, I want to know whether metalation is possible or not.

Offline rolnor

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Re: About borate esters...
« Reply #1 on: September 17, 2016, 06:55:25 AM »
Have you seen metalation with any ester, even good leavingroups like mesylate or triflate?  Maby you mean reductive elimination with palladium(0) then boronic acids are used.

Online Babcock_Hall

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Re: About borate esters...
« Reply #2 on: September 17, 2016, 01:40:59 PM »
As a rough first approximation, I would look at the pKa values of the conjugate acids of the leaving groups.

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