well, I can see that the two kheto groups and the hydroxy group have identical positions to each other in both acids. My problem is that I really don't have the knowledge (nor time to get it) about what to tell about them, from the questions I got. Are these acids common in our body ?
If yes, how are they produced in our body ?
If not, from what substances can our body alternatively create them ?
This is the part where Im pretty lost. I understand that both the acids is part of the metabolism of Leucine and Valine, and Leucine and Valine can't be produced in the body. But are they still common in the body, because of intake from food?
And, is there any link between these acids and low pH values of blood in a new born baby? In the clinical detective case the problem is that a baby have several problems:
dehydrated (estimated to lose 5% body water) and almost did not react. He was pale and had blue lips and fingertips. His heart rate was 170/min and a respiratory rate was 60/min. Blood pressure was low. His liver was enlarged. Reflexes were reduced and he was hypotonic in general. Laberatory values:
Ammonia 100 µM (normal values 30 – 60µM )
pH 7.15 (normal values 7.36 – 7.44)
Glucose 3.6 mmol/l (normal values 3.3 – 5.6 mmol/)
Lactate 1.3 mmol/l (normal values 0.5 – 1.5 mmol/l)
Semi-quantitative chemical analysis of urine revealed the increased amount of acids.Found results on detailed examination:
alpha-ketoisocaproic acid: highly elevated
alpha-ketoisovaleric acid: highly elevated
And my part of the task is to anwer the questions I wrote over, and preferably with a link to the values over here. I really don't see the link myself, so maybe some of you can help me out?
Anyway, thank you, I really appreciate it!