[chlorinecrown]

Hey,

I'm validating a method for quantifying Pt on ICP-OES this week. I took 7 replicates at around what I expected the reporting limit to be at 4 different wavelengths. One of them I can throw out, the other three read just about 10% higher than they ought to, with standard deviations at just about the level I wanted.

I want to just add specification to the method we actually use to multiply by x, where x gets my average to 100% recovery for the MDL determination rounds, and would be a required step before evaluating all future QC, etc.

If you were auditing me, would you accept my justification? (Our validation rounds show systemic bias, so we added a correction factor) What would be the physical significance of this factor? How would I justify multiplying instead of adding, other than "multiplying leads to good agreement with expectations, subtracting makes my blanks looks crazy"

The EPA MDL reference (December 2016) doesn't mention this at all.