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Topic: Measuring the Rate of Hydrolysis of Aspirin  (Read 2650 times)

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Offline cpatb

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Measuring the Rate of Hydrolysis of Aspirin
« on: July 29, 2018, 02:13:11 PM »
Hi, I am planning on conducting an experiment for my HL Chem IA where I measure the effect of temp change on the rate of hydrolysis of aspirin (C9H8O4 + H2O ⇌ C7H6O3 + CH3COOH), and I cannot figure out which indicator to use. I am pretty sure it involves some stoichiometry, but my brain has been on summer vacation for too long. I would really appreciate any help you guys can offer. Thank you in advance!!
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Offline chenbeier

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Re: Measuring the Rate of Hydrolysis of Aspirin
« Reply #1 on: July 29, 2018, 02:47:11 PM »
Probably you do some titrations. Indicator phenolpthalein or metylorange.
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Offline Borek

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Re: Measuring the Rate of Hydrolysis of Aspirin
« Reply #2 on: July 29, 2018, 04:12:23 PM »
A lot depends on the conditions you will perform the hydrolysis in. In general, if you start with a low pH (or high pH) solution chances are acid/base titration will be useless. OTOH, at pH close to neutral hydrolysis can be too slow to measure with titration.
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