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Author Topic: Help troubleshooting a Buchwald-Hartwig amination?  (Read 1231 times)

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minimumlong3

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Help troubleshooting a Buchwald-Hartwig amination?
« on: September 06, 2018, 10:53:11 AM »


Does anyone have any experience in Pd cross-coupling reactions that could help me? I'm trying to couple an aryl chloride (that has a alcohol protected by a TBDMS and an heterocycle) with a alkylamine with a phenol at the end of it. I'm getting weird products (multiple TBDMS signals when there should only be one). Also, my "product" tends to have a higher Rf than both of my reagents, if someone knows anything about this I would be very grateful!
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Borek

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Re: Help troubleshooting a Buchwald-Hartwig amination?
« Reply #1 on: September 06, 2018, 11:35:05 AM »

Please don't cross post.

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