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Topic: Organic reaction LSA  (Read 1547 times)

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Offline hayley4

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Organic reaction LSA
« on: November 02, 2018, 08:57:48 AM »
Hello !

i'm a pHD student, and i haven't done that much organic, but to solve a problem that I have in lab i need to know a reaction.
So i thought maybe someone can help me here?
it's a transformation of the peptide bond into a amide bond:  R-CONH-R to R-CONH2. Does anyone as a clue ?
Thanks a lot !
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Offline kriggy

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Re: Organic reaction LSA
« Reply #1 on: November 05, 2018, 04:52:28 AM »
That is a tricky one. I think you could try this method Org. Lett. 2017, 19, 1614−1617  using ammonia or some kind of ammonia equivalent (benzylamine followed by hydrogenation etc..) but IM not sure if it will work with amino acids, you have to try
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