Chemical Forums

Please login or register.

Login with username, password and session length

Sponsored links

Pages: [1]   Go Down

Author Topic: Friability tester in pharmaceutical industries  (Read 447 times)

0 Members and 1 Guest are viewing this topic.

browniee

  • Regular Member
  • ***
  • Mole Snacks: +0/-0
  • Offline Offline
  • Posts: 19
Friability tester in pharmaceutical industries
« on: December 09, 2018, 04:14:03 PM »

I realised that there are alot of pharmaceutical industries that set the number of rotations for the friability tester at 100 revolutions. Why is this so? why must it be at specifically 100 revolutions ?
Logged

sjb

  • Global Moderator
  • Sr. Member
  • ***
  • Mole Snacks: +211/-41
  • Offline Offline
  • Gender: Male
  • Posts: 3355
Re: Friability tester in pharmaceutical industries
« Reply #1 on: December 09, 2018, 10:51:00 PM »

Possibly a chicken and egg situation? The earliest machines allowed testing at this setting (due to electric frequencies? I don't know), so SOPs were written and applied with this in mind, and as such it became a de facto standard?
Logged

Borek

  • Mr. pH
  • Administrator
  • Deity Member
  • *
  • Mole Snacks: +1619/-395
  • Offline Offline
  • Gender: Male
  • Posts: 24732
  • I am known to be occasionally wrong.
    • Chembuddy
Re: Friability tester in pharmaceutical industries
« Reply #2 on: December 10, 2018, 05:56:25 AM »

I doubt it "must be". But definitely you want tests to be normalized, that means using identical settings everywhere. 100 rpm is a nice, easy to remember number, plus, as sjb wrote, it could have some historical reasons.

I know a story of an industrial lab where they run viscosity tests during resin synthesis to tell when to stop the polymerization. Viscosity was measured at some strange temperature, say 67 °C. Technically it could be any temperature from the 40-70 range or something like that, so why 67? Well, the only reason was, at the time the synthesis was set up (and the viscosity test was calibrated) that was the only setting available (because of some malfunction of the thermostat). It stick, as whole procedure was designed around it.
Logged
ChemBuddy chemical calculators - stoichiometry, pH, concentration, buffer preparation, titrations.info, pH-meter.info, PZWT_s1
Pages: [1]   Go Up
 

Mitch Andre Garcia's Chemical Forums 2003-Present.

Page created in 0.088 seconds with 23 queries.