March 28, 2024, 07:43:44 PM
Forum Rules: Read This Before Posting


Topic: Effect Ethanol has on pH  (Read 1420 times)

0 Members and 1 Guest are viewing this topic.

Offline jeffmoonchop

  • Full Member
  • ****
  • Posts: 334
  • Mole Snacks: +37/-5
  • Gender: Male
Effect Ethanol has on pH
« on: January 10, 2019, 01:05:26 PM »
Hi I'm working on process development for a formulation where to make the formulation ethanol has to be used as well as an acetate buffer. When the formulation is made the pH is 6.5 and the concentration of ethanol is around 17%.

After the formulation is made I remove the ethanol by dialysis because it is harmful on standing. I'm doing some experiments to find out the actual harmful effect of ethanol and to do that I need to make the same buffer mixture as the formulation is made it but without ethanol and at the same pH.

I've been told that ethanol may give a false value to the pH, so if I make the same solution without ethanol to pH 6.5, the 'real' pH will actually be different? Is this true and how can I correct the non-ethanol buffer according to the magnitude the ethanol changes the pH?

Offline Borek

  • Mr. pH
  • Administrator
  • Deity Member
  • *
  • Posts: 27633
  • Mole Snacks: +1799/-410
  • Gender: Male
  • I am known to be occasionally wrong.
    • Chembuddy
Re: Effect Ethanol has on pH
« Reply #1 on: January 10, 2019, 01:34:55 PM »
Technically pH is something defined for water, not for water/ethanol mixtures, so I would be ready for irreproducibility.
ChemBuddy chemical calculators - stoichiometry, pH, concentration, buffer preparation, titrations.info

Sponsored Links