Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: ace on October 21, 2007, 05:26:19 PM
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What is the mechanism tht is involved in adding chloroacetic acid to an amine? Does this reaction require basic conditions or will it simply add at neutral pH?
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Slightly basic conditions may be optimal. Otherwise the acidic proton may slow down the reaction rate by interferring with the nucleophilicity of the amine. It would be an a nucleophillic substitution reaction that avoids the need for a carbocation intermediate.
You didnt actually mean acid chloride, right?
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Thanks Fry for your response. I do meant chloroacetic acid. thanks
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Take a reaction in EDC add amines and KOH and heat to reflux now start addition of Chloro acetic acid in EDC .
You will find salt KCl which shows your reaction is going on.