[Hamoona14]

Hi guys,

I am trying to synthesize a compound via  diol desymmetrization reaction. I am going to be using a diol, diisopropylcarbodiimde and a copper box complex. Any ideas for the method!


Thank you

[Dan]

I am trying to synthesize a compound via  diol desymmetrization reaction. I am going to be using a diol, diisopropylcarbodiimde and a copper box complex. Any ideas for the method!

Is your goal to (a) synthesise the compound or (b) develop a new methodology?

If (a), why not use a known method for diol desymmetrisation (there are several already)?
If (b), look at the known methods for diol desymmetrisation and study their experimental procedures.

It's usually just a case of dissolving the reagents and the catalyst in a solvent. You will have identify good conditions experimentally.

[Hamoona14]

Thank you Dan,
  I have found method from Evans. as u said just  dissolving reagents but it gives very low yield and sometimes doesn't give me the required product,.so I am looking for different ideas to try.

[Dan]

You're not giving enough information for us to help you. Unless you give the details of what you want to achieve (at least answer my first question in post #2), exactly what you have attempted and exactly what is going wrong, we have no data on which to base a sensible suggestion.

I realise you may not be at liberty to discuss these details publicly for IP reasons, but if that is the case then asking on a public forum is probably a waste of time - you should discuss it with your advisor and colleagues at you institution if that is the situation.