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Topic: Can you decarboxylate alpha-hydroxy carboxylic acids with just heat?  (Read 4613 times)

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Offline Fry

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Is this possible? I did some searching and only found links with catalysts..

Offline Yarr

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Re: Can you decarboxylate alpha-hydroxy carboxylic acids with just heat?
« Reply #1 on: September 22, 2007, 05:20:57 PM »
The decarboxylation of alpha-hydroxyacids can be made by heating to ~190ÂșC in what is known as Blaise-Le Sueur degradation. The products are an aldehyde, water, and carbon monoxide: in general, heating RCHOHCO2H will give RCHO + CO + H2O. Here's an old reference for you: J. Chem. Soc., 1904, volume 85, page 827.
Alternatively, this can be done with LTA.

Offline Fry

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Re: Can you decarboxylate alpha-hydroxy carboxylic acids with just heat?
« Reply #2 on: September 24, 2007, 12:03:36 AM »
Thank you so much!

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