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Topic: Coupling Reaction  (Read 1502 times)

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Offline AlphaScent

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Coupling Reaction
« on: January 09, 2013, 10:23:49 AM »
In some reactions as the aliphatic chain increases the reactivity decreases.  What about specifically terminal alkyne couplings.

I know through experience that 5-Hexyn-1-ol can be couple after THP protection.

What about 11-Dodecyn-1-ol?

Thank you very much.  I am leaning to not a viable reaction due to the reactivity.
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Offline discodermolide

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Re: Coupling Reaction
« Reply #1 on: January 09, 2013, 10:30:24 AM »
Quote from: AlphaScent on January 09, 2013, 10:23:49 AM
In some reactions as the aliphatic chain increases the reactivity decreases.  What about specifically terminal alkyne couplings.

I know through experience that 5-Hexyn-1-ol can be couple after THP protection.

What about 11-Dodecyn-1-ol?

Thank you very much.  I am leaning to not a viable reaction due to the reactivity.

I see no difference at all. The 11-Dodecyn-1-ol will react just as well as the other compound.
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Offline AlphaScent

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Re: Coupling Reaction
« Reply #2 on: January 09, 2013, 02:01:42 PM »
Thanks Disco !!
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