Chemical Forums
Chemistry Forums for Students => High School Chemistry Forum => Topic started by: confusedstud on May 15, 2015, 11:49:19 AM
-
I am researching on the British Pharmacopoeia for Acetaminophen whereby the reaction between p-aminophenol and sodium nitroprusside (SNP) gave a blue coloured complex. I couldn't find any reactions between the two but i managed to find that the actual acetaminophen can react with the SNP to give a blue solution as well. (from this link: http://www.researchgate.net/publication/225196353_Selective_spectrophotometric_determination_of_paracetamol_with_sodium_nitroprusside_in_pharmaceutical_and_biological_samples )
In the reaction mechanism I saw that the amide group was untouched so can i assume that the same mechanism can occur just that instead of the amide functional group it has a NH2?
-
So far I know is the reaction of NPS with a phenolic OH-group to get a nitrite. -ON=O.
So I assume all phenols will react in this way. But maybe do atest and check different phenols and phenyl-amins.
-
So far I know is the reaction of NPS with a phenolic OH-group to get a nitrite. -ON=O.
So I assume all phenols will react in this way. But maybe do atest and check different phenols and phenyl-amins.
I found this link http://www.e-journals.in/PDF/V4N2/377-388.pdf but I am not too sure whether it is correct though. Because it contradicts with this other link i found https://books.google.com.sg/books?id=Rh3-BV9smfoC&pg=PA589&dq=4-aminophenol+legal%27s+reaction&hl=en&sa=X&ei=4eRZVeK-DcypuwSu5YGYAg&ved=0CBwQ6AEwAA#v=onepage&q=4-aminophenol%20legal's%20reaction&f=false
Which one do you think is more credible?