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Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: emy on October 17, 2006, 12:01:26 PM

Title: the function of NFAT in decoding of calcium signaling in T cells
Post by: emy on October 17, 2006, 12:01:26 PM

what part does the NFAT complex play in the decoding of calcium signals in the cell

Title: Re: the function of NFAT in decoding of calcium signaling in T cells
Post by: sdekivit on October 19, 2006, 05:03:03 PM

NFAT is a transcription factor that is activated by the Ca-dependant protein calcineurin resulting gene expression. Calcineurin is activated when intracellular Ca-concentration increase by activation of phospholipase C by cross-linking of the T-cell receptor. IP3 then releases Ca from the smooth ER into the cytosol, so it can bindt to calmodulin and calcineurin.

in combination with the transcription factors MAPk and NF-kB this induces T-cell proliferation and differentiation.