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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: minsc458 on July 14, 2018, 07:13:02 AM

Title: Equivalence salts
Post by: minsc458 on July 14, 2018, 07:13:02 AM

Hello, do you know the equivalence of the differents salts of this molecule :

10 mg Tranylcypromine sulfate Molecular Weight : 364.46 g/mol
10 mg Tranylcypromine hydrochloride Molecular weight :169.65 g/mol

10 mg Tranylcypromine hydrochloride will have 2.14 times more tranylcypromine than 10 mg Tranylcypromine sulfate.
Is it correct?

Thanks for your help

Title: Re: Equivalence salts
Post by: billnotgatez on July 14, 2018, 05:13:32 PM

Can we assume the following
 considering there are many results from searching

From PubChem

Tranylcypromine sulfate
  MW: 364.460 g/mol
  MF: C₁₈H₂₄N₂O₄S
Tranylcypromine hydrochloride
  MW: 169.652 g/mol
  MF: C₉H₁₂ClN
Tranylcypromine
  MW: 133.194 g/mol
  MF: C₉H₁₁N

Title: Re: Equivalence salts
Post by: minsc458 on July 14, 2018, 05:30:30 PM

Yes it's the first two results.

the difference in molecular weight means 10 mg of the sulfate form is two times less potent than 10 mg of the hydrochloride form ?

Title: Re: Equivalence salts
Post by: wildfyr on July 14, 2018, 05:48:39 PM

No, they are about the same. The sulfate has two transylamines to one sulfate, but the hydrochloride is 1 amine to each chloride. It's because sulfate is a divalent anion, and chloride is monovalent.

Title: Re: Equivalence salts
Post by: minsc458 on July 14, 2018, 05:58:16 PM

ok thanks for the explanation.