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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: awais on September 15, 2006, 03:24:04 AM

Title: conversion of chloropropanol to mercaptopropanol
Post by: awais on September 15, 2006, 03:24:04 AM

I have 2 questions:

1. I have to convert 1,3-dichloro-2-propanol to 1,3-dimercapto-2-propanol, using some safer method which should not effect the OH group.

2. How to convert the COOH group to ester. compound to be covert is 1,3-dibromo-2-carboxylic acid.

This is really nice forum where i found lot of solutions n i thank all of.

Title: Re: conversion of chloropropanol to mercaptopropanol
Post by: AWK on September 15, 2006, 05:30:44 AM

1. I think a formal double exchange reaction with KHS or NaHS will work
2. Use PBr3 followed by an alcohol.

Title: Re: conversion of chloropropanol to mercaptopropanol
Post by: awais on September 16, 2006, 06:45:10 AM

Thanks, do u have any procedure, i mean i m not a good chemist

Title: Re: conversion of chloropropanol to mercaptopropanol
Post by: AWK on September 18, 2006, 03:50:52 AM

Some excess of reagents are needed. Use anhydrous conditions in the reaction with PBr3.