Chemical Forums
Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: Elan on June 06, 2014, 07:31:44 PM
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Chiral columns are expensive, has anyone tried making one yourself? If so, what amount of what compound did you mix into your silica? I know it will vary depending on the compound I'm trying to isolate, but it would be helpful to have a place to start my brainstorming. Any amount of detail appreciated!!!
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If you put a chiral reagent in your mobile phase, you can get a chiral separation on any column. A pentaflurophenyl column is often a good choice for this sort of separation, sometimes providing a chiral separation with chiral modified eluent.
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sometimes providing a chiral separation with chiral modified eluent.
Sorry, what I meant to say was you can get a chiral separation on a pentafluoro column without using a chiral modifier in the eluent.