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Chemistry Forums for Students => Organic Chemistry Forum => Organic Chemistry Forum for Graduate Students and Professionals => Topic started by: dukealadinstardust on July 18, 2015, 10:51:57 AM

Title: Help. alternative base to DIPEA for an asymmetric henry reaction
Post by: dukealadinstardust on July 18, 2015, 10:51:57 AM

Next week i am hoping to do an asymmetric Henry reaction using a Co(salen) catalyst. the literature says that the reaction requires DIPEA/ DBU. However, the chemical stores is shut. I have been trying to look for an alternative in literature to no avail. i really want to get the reaction done next week and was wondering if any of you could suggest an alternative or link me to a paper.
Thanks
http://pubs.acs.org/doi/abs/10.1021/ol062282z
original paper

Title: Re: Help. alternative base to DIPEA for an asymmetric henry reaction
Post by: Dan on July 18, 2015, 12:15:00 PM

It will probably work with triethylamine, but the selectivity may change. Do you have dicyclohexylmethylamine?

Have you checked the screening tables in the Yamada papers for clues?

You will probably just have to screen conditions with what you've got in the lab. There's no guarantee that DIPEA is the best base for your molecule.