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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: shrikantvarma on January 05, 2011, 11:20:19 AM

Title: weinreb amide ketone preparation??
Post by: shrikantvarma on January 05, 2011, 11:20:19 AM

what is the ideal condition while preparation of ketone by using weinreb amide??
my meaning is addition of weinreb amide to grignard is more favourable or addition of
grignard to weinreb amide??
which way will give ketone ??

Title: Re: weinreb amide ketone preparation??
Post by: MissPhosgene on January 05, 2011, 09:57:21 PM

Add the grignard to the amide.

do you know why that is better than adding the amide to a solution of grignard reagent?

Title: Re: weinreb amide ketone preparation??
Post by: AC Prabakar on January 07, 2011, 03:47:34 AM

Probably to avoid over addition product.