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Topic: Imidazole + grignard  (Read 2794 times)

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Offline mizna.z

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Imidazole + grignard
« on: July 10, 2009, 05:46:56 PM »
what would happen if imidazole acted as an acid to react with Ch3MgBr (a base).
im thinking the proton on the N is too acidic to allow Ch3MgBr to attack there. so if the other N attacks, would would the product look like?
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Offline nj_bartel

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Re: Imidazole + grignard
« Reply #1 on: July 10, 2009, 11:11:20 PM »
Why would a proton being 'too acidic' be a problem?  I'd pick the proton on the pyrrole like nitrogen for site of deprotonation.
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