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Topic: acid/base centers  (Read 1719 times)

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Offline pvz

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acid/base centers
« on: September 15, 2013, 06:12:34 AM »
I don't understand why pKa1 is so low? I would think it is a base not acid because piperazine is a base.

Thank you very much.
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Offline pvz

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Re: acid/base centers
« Reply #1 on: September 16, 2013, 02:38:32 AM »
Anyone? ???
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Offline Cooper

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Re: acid/base centers
« Reply #2 on: September 16, 2013, 08:42:55 PM »
Quote from: pvz on September 15, 2013, 06:12:34 AM
I don't understand why pKa1 is so low? I would think it is a base not acid because piperazine is a base.

Thank you very much.

Hi pvz,


Perhaps steric effects are the cause of the nitrogen's acidity, because of how bulky the two phenyl groups are. Not too sure myself, just a thought.
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~Cooper :)
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