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Topic: Catalytic Mechanism of Lysozyme  (Read 5978 times)

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Offline mstrrogers

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Catalytic Mechanism of Lysozyme
« on: April 03, 2009, 12:20:24 PM »
Why does ASP52(as an amino sidechain) help stabilize NAC acid reaction intermediate?
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Offline mstrrogers

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Re: Catalytic Mechanism of Lysozyme
« Reply #1 on: April 03, 2009, 12:42:01 PM »
The free carboxyl group of glutamic acid is a hydrogen ion donor. This would break the already-strained bond between the oxygen atom and the carbon atom of ring. The resulting positive charge on C1 can be stabilized by ionized Asp-52.

is this the correct answer?
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