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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: AllylicAzideUMN on May 09, 2020, 12:57:05 AM

Title: "Holy Grails" of Modern Organic Chemistry
Post by: AllylicAzideUMN on May 09, 2020, 12:57:05 AM

I am wondering what the community here believes to be the most coveted and most valuable advances the field of organic chemistry is working towards; the transformations/selectivities we would all love to achieve, but none of us can yet: the holy grails of our field.

My initial guesses would involve selective catalytic activation of C(sp³)-H bonds, machine-learning-driven reaction optimization, and broadly-applicable base metal catalysts.

I would love to hear everyone's opinions.   

Title: Re: "Holy Grails" of Modern Organic Chemistry
Post by: rolnor on May 09, 2020, 04:35:52 PM

If it was possible to create a carbon.carbon bond from twoo alcohols, maybe make a thiocarbonate of the two alcohols and heat it with Bu3SnH to create two radicals that combine to form a new bond. This would be very powerful I imagine. Maybe it will be my next project. It will not be easy, people have tried this off course.

Title: Re: "Holy Grails" of Modern Organic Chemistry
Post by: rolnor on May 10, 2020, 05:13:50 AM

I should ad that if you have a alcoholthiocarbonylderivative you can react this with allyltributyltin to get R-Allyl so this is not so far away really.