Chemical Forums
Specialty Chemistry Forums => Biochemistry and Chemical Biology Forum => Topic started by: spirochete on March 24, 2008, 08:29:19 PM
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How many times should you expect to find a six base pair DNA sequence in a 11,000 BP fragment of DNA?
I am 90% lost on how to do this. I feel like part of the answer should involve raising 0.25 to the sixth power, because that's the probability of finding a paticular sequence in six nucleotides.
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How many times should you expect to find a six base pair DNA sequence in a 11,000 BP fragment of DNA?
I am 90% lost on how to do this. I feel like part of the answer should involve raising 0.25 to the sixth power, because that's the probability of finding a paticular sequence in six nucleotides.
1) Are A-T / T-A and G-C /C-G equally likely in a DNA molecule?
2) Are you allowing for overlaps?
If you allow for overlapping then the particular sequence you are looking for will have an effect on the expected value.
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I believe we can assume that AT/CG are equally likely, and I'm not sure if we're allowing for overlaps. I think this is how the problem was supposed to be solved:
(O.25^6)(11,000)
I'm not sure if this method accounts for overlaps. It seems like it does.
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I believe we can assume that AT/CG are equally likely, and I'm not sure if we're allowing for overlaps. I think this is how the problem was supposed to be solved:
(O.25^6)(11,000)
I'm not sure if this method accounts for overlaps. It seems like it does.
It does but it ignores the dependence between the overlaps