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Chemistry Forums for Students => Organic Chemistry Forum => Topic started by: shrikantvarma on September 28, 2010, 11:27:30 AM

Title: trimethylsilylcyanide reaction work up
Post by: shrikantvarma on September 28, 2010, 11:27:30 AM

i am doing cyanohydrin preparation  for that i want to use  trimethylsilyl cyanide ,but i dont know procedure for work up of trimethylsilyl cyanide
pls.explain??

Title: Re: trimethylsilylcyanide reaction work up
Post by: discodermolide on September 29, 2010, 11:35:38 AM

Quote from: shrikantvarma on September 28, 2010, 11:27:30 AM

i am doing cyanohydrin preparation  for that i want to use  trimethylsilyl cyanide ,but i dont know procedure for work up of trimethylsilyl cyanide
pls.explain??

just do a normal extractive work up, I assume you are not using an excess of TMSCN?

Title: Re: trimethylsilylcyanide reaction work up
Post by: shrikantvarma on September 29, 2010, 12:55:55 PM

thanks for comment i am using excess TMSCN ,i am doing neat reaction ??

Title: Re: trimethylsilylcyanide reaction work up
Post by: discodermolide on September 29, 2010, 01:25:22 PM

Quote from: shrikantvarma on September 29, 2010, 12:55:55 PM

thanks for comment i am using excess TMSCN ,i am doing neat reaction ??

then remove it by Vac distillation. A Rotavap with H2O vac <10mBar @ 30-40°C should be good enough, if your product is thermally stable